The anti-wrinkle octapeptide SNAP-8™ is an extension of the renowned hexapeptide Argireline®. Specifically designed to address facial wrinkles induced by muscle contractions, particularly in the forehead and around the eyes, SNAP-8™ mimics the N-terminal end of SNAP-25. It competes with SNAP-25 for a position in the SNARE complex, modulating its formation. By destabilizing the SNARE complex slightly, the vesicle's efficient neurotransmitter release is hindered, leading to the attenuation of muscle contraction and preventing the development of lines and wrinkles.
Similar to Argireline, SNAP-8™ inhibits SNARE complex formation and catecholamine release, resulting in a reduction in the severity of existing facial wrinkles and demonstrated effectiveness in preventing their formation with regular use. Clinical studies show a decrease in the severity of wrinkles around the eyes by up to 63.13%. Both in vivo and in vitro efficacy testing indicates that SNAP-8™ is approximately 30% more active than its parent peptide, Argireline. Supplied by the manufacturer, this product contains 0.05% SNAP-8™ powder, also known as Acetyl Octapeptide-3.
SNAP-8™ stands out as a safer, more cost-effective, and milder alternative to Botulinum Toxin, targeting the same mechanism of wrinkle formation but through a distinct approach. It can be seamlessly incorporated into cosmetic formulations such as emulsions, gels, and serums where the reduction of deep lines or wrinkles in the forehead or around the eyes is desired.
INCI: Water (and) Acetyl Octapeptide-3
SNAP-8 can be incorporated at the final stage of the manufacturing process, provided the temperature is below 40°C (104°F). For storage it is recommended to store at 4°C (39°F). In rare cases, refrigerated storage of SNAP-8™ Solution can cause precipitation of the preservative. This does not affect the integrity of the product.
Incorporation: Add at the end of the emulsion, at cool down, below 40C (104F).
Recommended Usage Percentage: 3-10%
Appearance: Water-like liquid, odorless
Preservative: Caprylyl Glycol
Storage: Refrigeration recommended at 39.2°F (4°C)